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Consulting
• Library for Interdisciplinary Statistical Analysis (LISA)

Professor, 2002, Department of Statistics
Research Professor, 2002, Virginia Bioinformatics Institute
Adjunct Professor, 1988

Office: 410A Hutcheson Hall
Fax: (540) 231-3863
Email: inah@vt.edu
VBI Office: Virginia Bioinformatics Institute, Bioinformatics Facility I (0477)
Phone: (540) 231-3135
Fax: (540) 231-2606
Webpage: https://www.vbi.vt.edu/article/articleview/ 277

Link to syllabi for all courses.

Research areas:

quantitative and statistical genetics, genetic architecture of complex traits, QTL mapping, pedigree analysis, genetic parameter estimation, variance components estimation, generalized linear mixed models, design and analysis of microarray expression experiments, design and analysis of systems genetics experiments, gene network inference, structural equation modeling

Selected Publications:

• Uimari, P. and I Hoeschele. 1997. Mapping linked quantitative trait loci using Bayesian analysis and Markov chain Monte Carlo algorithms. Genetics 146:735-743.

• Zhang, Q., D. Boichard, M. C. Bishop, I. Hoeschele, C. Ernst et al.. 1998. Mapping quantitative trait loci for milk production and health of dairy cattle in a large outbred pedigree. Genetics 149:1959-1973.

• Du, F., I. Hoeschele and K.M. Gage-Lahti (1999) Estimation of additive and dominance variances components in finite polygenic models and complex pedigrees. Genetical Research 74:179-187.

• Du, F. and I. Hoeschele (2000) Estimation of additive, dominance, and epistatic variance components using finite-locus models implemented with a single-site Gibbs and a descent graph sampler. Genetical Research 76:187-198.

• Du, F. and I. Hoeschele (2000) A note on genotype and allele elimination in complex pedigrees with incomplete genotype data. Genetics 156:2051-2062.

• Thaller G., and I. Hoeschele (2000) Fine-mapping of quantitative trait loci in half-sib families using current recombinations. Genetical Research 76:87-104.

• Von Rohr, P. and I. Hoeschele (2001) Robust Bayesian analysis using skewed Student-t distributions. Genetics, Selection, Evolution 34:1-21.

• Freyer G., P. Sorensen, C. Kuhn, R. Weikard and I. Hoeschele (2003) Search for pleiotropic QTL on chromosome BTA6 affecting milk production traits. J. Dairy Sci. 86: 999-1008.

• Hoeschele I. (2003) Mapping of quantitative trait loci in complex pedigrees. Handbook of Statistical Genetics, DJ Balding, M Bishop & C Cannings (eds.), Wiley, Vol. 2, pp. 477-519.

• Gao, G., and Hoeschele, I. (2004) Conditional probability methods for haplotyping in pedigrees. Genetics 167: 2055-2065..

• De la Fuente A, Bing N, Hoeschele I & Mendes P (2004) Discovery of topologically meaningful associations in genomic data using partial correlation coefficients. Bioinformatics 20: 3565-3574.

• Pfister-Genskow, M., Myers, C., Childs, L., Lacson, J., Betthauser, J., Gouleke, Forsberg, E., P., Zheng, Y., Leno, G., Schultz, R., Yang, X., Hoeschele, I., and Eilertsen, K.J. (2004) Identification of differentially expressed genes in individual bovine preimplantation embryos produced by nuclear transfer: Improper reprogramming of genes required for trophoblast development. Biology of Reproduction 72: 546-555.

• Hoeschele, I., and Li, H. (2004) A note on joint versus gene-specific mixed model analysis of microarray gene expression data. Biostatistics 6: 183-186.

• Bing, N. and Hoeschele, I. (2005) Genetical genomics analysis of a yeast segregant population for transcription network inference. Genetics 170: 533-542.

• Bing, N., Hoeschele, I., Ye, K. and Eilertsen, K.J. (2005) Finite mixture model analysis of microarray expression data on samples of uncertain biological type with application to reproductive efficiency. Veterinary Immunology and Immunopathology 105: 187-196.

• Gao, G., and Hoeschele, I., (2005) Approximating identity-by-descent matrices using multiple haplotype configurations on pedigrees. Genetics 171:365-376.

• Betthauser, J.M., Pfister-Genskow, M., Xu, H., Gouleke, P.J., Lacson, J.C., Koopang, R.W., Liu, B., Hoeschele, I., Eilertsen, K.J., and Leno, G.H. (2006) Nucleoplasmin facilitates reprogramming and in vivo development of bovine nuclear transfer embryos. Molecular Reproduction and Development 73:977-986.

• Stock, K.F., Distl, O., and Hoeschele, I. (2007) Influence of priors in Bayesian estimation of genetic parameters for multivariate threshold models using Gibbs sampling. Genetics-Selection-Evolution 39:123-137.

• Stock, K.F., Distl, O., and Hoeschele, I. (2007) Bayesian estimation of genetic parameters for multivariate threshold and continuous phenotypes and molecular genetic data using Gibbs sampling. BMC Genetics (in press).

• Gao, G. and I. Hoeschele (2007) A note on a haplotyping method in pedigrees. Genetics, Selection, Evolution (in press).

• Hoeschele I. (2007) Mapping quantitative trait loci in outbred pedigrees. Handbook of Statistical Genetics, DJ Balding, M Bishop & C Cannings (eds.), Wiley, p. 477-525 (in press).

Grants:

• National Institutes of Health, R01 GM66103-01, (2002-2006), “Polygenic linkage and linkage disequilibrium mapping”, $320,708, I. Hoeschele.

• National Science Foundation DBI-0211863, (2002-2008), “Dissecting soybean resistance to Phytophthora by QTL analysis of host and pathogen expression profiles”, $6,764,465, B.M. Tyler, M.A. Saghai Maroof, G.R. Buss, I. Hoeschele, K. Ye, A. Dorrance, S. St. Martin.

• Comprehensive Cancer Center Of Wake Forest University, (2006-2010), “Biostatistics Consulting”, $255,612, I. Hoeschele.

• National Institutes of Health (2007-2011), “Haplotyping and QTL mapping in pedigrees with missing data”. G. Gao, P.I. et al., I Hoeschele, co-P.I.

Awards:

• German Foreign Academic Exchange Organization Fellow, Station de Genetique Quantitative et Appliquee, Jouy-en-Josas, France, 1985.

• Young Scientist's Research Award of the European Association for Animal Production (EAAP), 1985.

• Summa Cum Laude Dissertation Award, Hohenheim University, Stuttgart, Germany, 1986.

• Postdoctoral Fellowship of the German National Science Foundation, 1986-87.

• Visiting Professor, Australian Meat Corporation Fund, Animal Genetics and Breeding Unit, University of New England, Armidale, NSW 2315, Australia, 1993.

• Visiting Professor, Human Capital and Mobility Fund, Wageningen Agricultural University, The Netherlands, 1995.

• Sabbatical (NIH-funded), Department of Statistics, North Carolina State University (host: Dr. B.S. Weir), 1999.

Courses taught:

Stat 5554 (Co)variance Components Estimation

Stat 5564 Statistical Genetics

Other Activities:

Associate Editor (Biometrics, Genetics-Selection-Evolution), member of the University-wide Genetics Ph.D. program in Genetics, Bioinformatics and Computational Biology (GBCB) (steering and admissions committees)

Professional Memberships:

American Statistical Association, Genetics Society of America, Sigma Xi - The Scientific Research Society.