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• Laboratory for Interdisciplinary Statistical Analysis (LISA)

Professor, 2002, Department of Statistics,
Virginia Tech
Professor, 2002, Virginia Bioinformatics Institute,
Virginia Tech Adjunct Professor, Wake Forest University School of Medicine, Winston-Salem, NC
Adjunct Professor, Virginia Tech Carillion School of Medicine, Roanoke, VA.

VBI Office: 263B, Virginia Bioinformatics Institute, Bioinformatics Facility (0477)
Phone: (540) 231-3135
Fax: (540) 231-2606
Email: inah@vbi.vt.edu
Webpage: https://www.vbi.vt.edu/article/articleview/ 277

Research areas:

Statistical genetics, genetic architecture of complex traits, QTL linkage and association analyses, Systems Genetics, design and analysis of microarray gene expression experiments, gene network inference, Structural Equation Modeling, Bayesian parametric and nonparametric methods, generalized linear mixed models.

Selected Publications:

(Selected from 86 peer-reviewed publications)

• Kakko, S., Kelloniemi, J., von Rohr, P., Hoeschele, I., Tamminen, M., Brousseau, M.E., Kesäniemi, Y.A. and Savolainen, M.J. (2002). ATP-binding cassette transporter A1 locus was not a major locus for HDL-C regulation in a population with high risk of coronary heart disease. Arteriosclerosis, 166, pp. 285-290.

• De la Fuente, A., Bing, N., Hoeschele, I. and Mendes, P. (2004). Discovery of topologically meaningful associations in genomic data using partial correlation coefficients. Bioinformatics, 20, pp. 3565-3574.

• Hoeschele, I. and Li, H. (2005). A note on joint versus gene-specific mixed model analysis of microarray gene expression data. Biostatistics, 6, pp. 183-186.

• Gao, G. and Hoeschele, I. (2005). Approximating identity-by-descent matrices using multiple haplotype configurations on pedigrees. Genetics, 171, pp. 365-376.

• Stock, K.F., Distl, O., and Hoeschele, I. (2007) Influence of priors in Bayesian estimation of genetic parameters for multivariate threshold models using Gibbs sampling. Genetics-Selection-Evolution 39:123-137.

• Gao, G. and I. Hoeschele (2007) A note on a haplotyping method in pedigrees. Genetics, Selection, Evolution 40: 25-36.

• Stock, K.F., Hoeschele, I. and Distl, O. (2007) Bayesian estimation of genetic parameters for multivariate threshold and continuous phenotypes and molecular genetic data in simulated horse populations using Gibbs sampling. BMC Genetics 8:19.

• Hoeschele, I. (2007). Mapping quantitative trait loci in outbred populations. Handbook of Statistical Genetics, DJ Balding, M Bishop & C Cannings (eds.), New York: John Wiley, Vol. 1, pp. 623-677.

• Bao, L. and Hoeschele, I. (2008). Quality assessment for short oligonucleotide microarray data: Comment. Technometrics, 50, pp. 268-271.

• Liu, B., de la Fuente, A. and Hoeschele, I. (2008). Gene Network Inference via Structural Equation Modeling in Genetical Genomics Experiments. Genetics, 178, pp. 1763-1776. PMCID: PMC2278111.

• Gao, G., Allison, D.B. and Hoeschele, I. (2008). Haplotyping Methods in Pedigrees. Human Heredity, 67, pp. 248-266.

• Zhou, L., S. X. Mideros, L. Bao, R. Hanlon, F. Arredondo, S. Tripathy, K. Kampis, A. Jerauld, C. Evans, S.K. St. Martin, S. Maroof, I. Hoeschele, A.E. Dorrance and B.M. Tyler (2009) Infection and genotype remodel the entire soybean transcriptome. BMC Genomics 10:49.

• Liu, B., Hoeschele, I. and de la Fuente, A. (2009). Inferring gene regulatory networks from genetical genomics data. In: Computational methodologies in gene regulatory networks. S. Das, D. Caragea, W.H. Hsu and S.M. Welsh (eds.), IGI Global (in press).

• Armenta, J., Lazar, I.M. and Hoeschele, I. (2009). A quantitative proteomic study of the MCF-7 breast cancer cell line using iTRAQ/PQD linear ion trap MS technology. J. Amer. Soc. Mass Spectrom, (in press).

• Huang, H., H. Zhu, F. Cheng, I. Hoeschele and F. Zou (2009) Gaussian process based Bayesian semiparametric quantitative trait loci interval mapping. Biometrics (in press).

Grants:

Ongoing:

• RHL092572A             Davy (PI)                                8/01/2008-7/31/2010
  National Institutes of Health
  Angiotensis II Receptor Blockage and Adipose Tissue Inflammation in Obesity
  Role: Co-PI

• 208-11-110438 T-055810-802-1   Hoeschele (PI)  07/01/07-06/30/09
  Wake Forest University (NIH)
  Research Collaboration and TSI Program
  Role: PI

• 1R01GM073766-01A2           Gao (PI)                      06/1/2007-5/31/2012
  National Institutes of Health
  Haplotyping and QTL mapping in pedigrees with missing data
  Role: PI

• P30 CA12197             Torti (PI)                              02/01/2006-01/31/2012
  WFUHS (NIH/NCI)
  Comprehensive Cancer Center of Wake Forest University
  Biostatistics Consulting
  Role: PI

• 1R01HL101250-01                 Liu (PI)                       03/01/10 - 02/2/15
  National Institutes of Health
  Epigenome-wide association study of DNA methylation and atherosclerosis
  Role: Co-PI

Recently Completed:

• DBI-021863                Tyler (PI)                                 10/1/2002-9/30/2008
  National Science Foundation
  Dissecting soybean to Phytophthora by QTL analysis of host and pathogen expression profiles
  Role: Co-PI

• R01 GM66103-01                 Hoeschele (PI)              09/1/2002-8/31/2006
  National Institutes of Health
  Polygenic linkage and linkage disequilibrium mapping
  Role: PI

Awards:

• German Foreign Academic Exchange Organization Fellow, Station de Genetique Quantitative et Appliquee, Jouy-en-Josas, France, 1985.

• Young Scientist's Research Award of the European Association for Animal Production (EAAP), 1985.

• Summa Cum Laude Dissertation Award, Hohenheim University, Stuttgart, Germany, 1986.

• Postdoctoral Fellowship of the German National Science Foundation, 1986-87.

• Visiting Professor, Australian Meat Corporation Fund, Animal Genetics and Breeding Unit, University of New England, Armidale, NSW 2315, Australia, 1993.

• Visiting Professor, Human Capital and Mobility Fund, Wageningen Agricultural University, The Netherlands, 1995.

• Visiting Professor, Department of Statistics, North Carolina State University (host: Dr. B.S. Weir), 1999.

Courses taught:

Stat 5564 Statistical Genetics

STAT 5984 Special Topics in Statistical Genomics and Bioinformatics

Other Activities:

Associate Editor (Biometrics (past), Genetics, Genetics-Selection-Evolution), member of the University-wide Genetics Ph.D. program in Genetics, Bioinformatics and Computational Biology (GBCB) (steering and admissions committees)

Professional Memberships:

American Statistical Association, Genetics Society of America, Sigma Xi - The Scientific Research Society.